Laboratory Test Information Guide

Details for Alpha 1-Antitrypsin Clearance, Feces and Serum

Test Name: Alpha 1-Antitrypsin Clearance, Feces and Serum
Alternate Name(s): Alpha-1 Antitrypsin Clearance
Alpha-1-Antitrypsin Clearance
Alpha1 Antitrypsin Clearance
Alpha 1 Antitrypsin Clearance
Laboratory: Core
Specimen Type: FECES:
Collect all feces produced within a 24-hour period in fecal collection containers provided by the Core Laboratory upon request. If no specimen is obtained within 24 hours, extend collection time to 48 to 72 hours. Document time frame (duration of collection) on container.


5 mL Gold top Vacutainer tube

0-2 years: 2 x 0.5 mL Red or Gold top Microtainer
2-10 years: 3 mL Red top Vacutainer tube
Collection Information: Both feces and serum are required.

Blood must be drawn during the stool collection period.

Minimum volume of serum required is 0.5 mL. Ship entire fecal collection.

Use of any preservative/fixative will be cause for sample rejection.
Test Schedule: Referred out Monday-Thursday
Turnaround time from when specimen
is received in testing laboratory:
10 days
Reference Range: Clearance: ≤27 mL/24 hours

Fecal alpha1-antitrypsin: ≤54 mg/dL

Serum alpha1-antitrypsin: 100-190 mg/dL
Effective Date: 2019-10-22
Revised Date:  
Critical Value:  
Interpretive Comments: Patients with protein-losing enteropathies generally have alpha1-antitrypsin clearance values >50 mL/24 hours.

Borderline elevations above the normal range are equivocal for protein-losing enteropathies.
Special Processing:  
Method of Analysis: Nephelometry
Critical Information Required:  
Storage & Shipment: Store and ship feces (entire collection) and serum frozen. Feces and serum should be shipped together. Specimens shipped separately may delay testing.
System Codes: 
Referred To: In-Common Laboratories

Questions? Comments? Contact Laura Gopaul