Laboratory Test Information Guide

Details for Anti Histone Group,Serum

Test Name: Anti Histone Group,Serum
Alternate Name(s): HIST
Laboratory: Clinical Immunology
Specimen Type: 5 mL Gold top Vacutainer tube or 6 mL Red top Vacutainer tube as well as EDTA, heparin or citrate plasma

0-2 yrs: Red 1.0 pk.
2-10 yrs: 2 mL Red top
Collection Information: Minimum volume of serum required is 0.1 mL.
Test Schedule: Batch Analysis
Turnaround time from when specimen
is received in testing laboratory:
10 days
Reference Range: Negative: ≤ 0.9
Positive: > 0.9
Effective Date: 2010-04-07
Revised Date: 2018-08-08
Critical Value:  
Interpretive Comments: Histone antibodies are the major antibody found in 50-90% drug-induced lupus erythematosus. As well, histone antibodies are found along with other antibodies in 20-50% of Systemic Lupus Erythematosus and 10-15% of Rheumatoid Arthritis, Mixed Connective Tissue Disease and Progressive Scleroderma.

This test does not distinguish histone class (H1, H2a, H2b, H3, H4).
Special Processing:  
Comments: A single autoantibody test is not diagnostic and should not be used to determine course of treatment. The test result must be evaluated with consideration of clinical presentation, patient history and other laboratory tests.
Method of Analysis: Euroimmun Analyzer I-ELISA
Critical Information Required:  
Storage & Shipment: Serum can be stored for up to 21 days at 2 8 oC. For longer storage, store at -20 oC.
System Codes: 
Referred To:  

Questions? Comments? Contact Laura Gopaul