Laboratory Test Information Guide

Details for Anti-Acetylcholine Receptor Antibodies, Serum

Test Name: Anti-Acetylcholine Receptor Antibodies, Serum
Alternate Name(s): Acetylcholine Receptor Antibodies
Laboratory: Core
Specimen Type: Adult:
1-2 x 5 mL Gold top Vacutainer tubes

2-10 years: 1-3 x 3.5 mL Gold top Vacutainer tubes
Collection Information: 2-5 mL serum required for testing
Requisition: UBC Neuro-Immunology Laboratory Requisition must be completed by neurologist or ophthalmologist
Test Schedule: Referred out Monday
Turnaround time from when specimen
is received in testing laboratory:
10 days
Reference Range: Absent
Effective Date: 2017-11-07
Revised Date: 2020-07-20
Critical Value:  
Interpretive Comments:  
Special Processing: Centrifuge at 4 C, transfer serum to cryovials and store at 4 C.
Comments: Associated with Myasthenia Gravis.

Qualitative assay is performed first. If negative, reflexing to anti-muscle-specific tyrosine kinase (anti-MuSK) antibody testing is performed if requested on the requisition form. If qualitative assay is positive, assay is repeated with cold alpha-bungarotoxin to rule out non-specific binding. If qualitative test is truly positive, quantitative test is performed. If a previous sample has been received from the patient, it will be included in the quantitative test to allow comparison of antibody titers between samples.
Method of Analysis: KRONUS 125I isotope method
Critical Information Required:  
Storage & Shipment: Store serum at 4 C and ship with ice packs.
System Codes: 
Referred To: Neuro-Immunology Laboratory
University of British Columbia Hospital
Room S-157, 2211 Wesbrook Mall
Vancouver, B.C, Canada
V6T 2B5

Questions? Comments? Contact Laura Gopaul