| Test Name: | Anti-SARS-CoV-2 Total Antibody |
| Alternate Name(s): | Anti-SARS-CoV-2 Antibody
COVID Serology
Anti-SARS-CoV-2 (IgG + IgM)
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| Laboratory: | Core |
| Specimen Type: | Adult:
4.5 mL Green (Lithium Heparin) top Vacutainer
Serum from a 5 mL Gold top or 6 mL Red top is also acceptable.
Pediatric:
0-2 years: 0.5 mL Green or Gold top Microtainer
2-10 years: 3 mL Green top or 2 mL Gold top tube |
| Collection Information: | Collect blood aseptically in a Vacutainer tube. |
| Requisition: | GENERAL LABORATORY REQUISITION |
| Test Schedule: | Monday - Friday
0800 - 1600 h |
Turnaround time from when specimen
is received in testing laboratory: | | | |
| Reference Range: | See report |
| Effective Date: | 2020-08-01 |
| Revised Date: | 2020-01-15 |
| Critical Value: | |
| Interpretive Comments: | Interpretive Comments: Testing detects both IgG and IgM antibodies (total) to SARS-CoV-2 nucleocapsid (N) antigen.
Negative Results:
Negative results do not rule out acute SARS-CoV-2 infection. If acute infection is suspected, consider SARS-CoV-2 RNA testing or repeat testing in 7 to 10 days. False-negative results may occur in immunocompromised individuals or those with mild illness. Negative results do not preclude SARS-CoV-2 infection and should not be used as the sole basis for patient management decisions.
Positive Results:
Presence of SARS-CoV-2 antibodies indicates current or previous infection. False-positive results may occur due to cross-reacting antibodies or other causes. It is unknown whether antibodies indicate protective immunity.
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| Special Processing: | |
| Comments: | Serology testing examines a person’s blood to see if they have antibodies to COVID-19. Testing detects both IgG and IgM antibodies (total) to SARS-CoV-2 nucleocapsid (N) antigen of the SARS-CoV-2 virus.
Serology testing is limited to the currently approved uses in Ontario (See PHO COVID-19 Serology) including:
• The investigation of suspected cases of Multisystem Inflammatory Syndrome in Children (MIS-C)
• With Approval: Serology may be considered in patients with severe illness who have tested repeatedly negative by PCR and where serology results would be a helpful adjunctive tool for clinical/public health action and decision making
Serology testing should NOT be used for:
• the diagnosis of acute infection or determining if a patient is infectious
• determining immune status of the patient
Please contact Dr Michael Knauer, Clinical Biochemist (x52237 or pager 17130) for questions and approval
|
| Method of Analysis: | Test performed by Roche Elecsys Anti-SARS-CoV-2 Electrochemiluminescence immunoassay targeting the nucleocapsid (N) antigen. |
| Critical Information Required: | |
| Storage & Shipment: | Samples stable 7 days at 2-8 0C, freeze at -20 0C for longer storage. |
| System Codes: | | |
| Referred To: | |
