Laboratory Test Information Guide

Details for Autoimmune Encephalitis Panel

Test Name: Autoimmune Encephalitis Panel
Alternate Name(s): Anti-NMDAR
Anti-LGI1
Anti-CASPR2
Anti-AMPAR1/R2
Anti-GABARB1/B2
Anti-DPPX
Anti-GAD65
Anti-IgLON5
Encephalitis
Laboratory: Clinical Immunology
Specimen Type: Adult:
5 mL Gold top Vacutainer tube or 6 mL Red top Vacutainer tube as well as EDTA, heparin or citrate plasma.

Pediatric:
0-2 years: Red 0.5 Microtainer
2-10 yrs: 2 mL Red top
CSF will also be accepted.
Collection Information: Minimum volume required for testing is 0.5 mL
Requisition: GENERAL LABORATORY REQUISITION
Test Schedule: Batch analysis
Turnaround time from when specimen
is received in testing laboratory:
 
Routine
15 days
Stat
N/A
 
Reference Range:  
Effective Date: 2019-02-26
Revised Date: 2019-07-12
Critical Value:  
Interpretive Comments: Positive result is indication of antibody-mediated encephalitis.
Special Processing:  
Comments: This test is available to neurologists at LHSC/SJHC and accepted from referred in locations.
A screening test and on its own does not confirm the diagnosis of autoimmune encephalitis and should not be used to determine course of treatment.
The test result must be evaluated with consideration of clinical presentation, patient history and other laboratory tests.
Method of Analysis: Immunofluorescence Assay (IFA) using
tissue immunohistochemistry in parallel with the cell-based assay.
Critical Information Required: Each sample must be submitted with a clinical questionnaire completed by the treating physician, which should take no more than 10-15 minutes to complete.

Clinical Questionnaire
Storage & Shipment: Sample can be stored for up to 14 days at 4oC. For longer storage, store at -20oC.
Send samples together with a completely filled out questionnaire.
System Codes: 
Cerner
AEPS for serum AEPCSF for CSF
 
Referred To:  

Questions? Comments? Contact Laura Gopaul