Laboratory Test Information Guide

Details for Copeptin (Surrogate Measure of Anti-Diuretic Hormone), Plasma/Serum

Test Name: Copeptin (Surrogate Measure of Anti-Diuretic Hormone), Plasma/Serum
Alternate Name(s): ADH
Antidiuretic hormone
Vasopressin
Arginine Vasopressin
AVP
ProAVP
Laboratory: Endocrinology
Specimen Type: Adult:
4.5 mL Light Green top (Li-Heparin) Vacutainer tube

Pediatric:
0-2 years: 0.5 mL Light Green top (Li-Heparin) Microtainer
2-10 years: 3 mL Light Green top (Li-Heparin) Vacutainer tube

Red or Gold top tubes are acceptable.

Lavender (EDTA) top tubes are NOT preferred. If EDTA plasma is being sent for testing, the laboratory must be informed.
Collection Information: Minimum volume of plasma or serum required is 500 L for adult samples or 250 L for pediatric samples.
Requisition: GENERAL LABORATORY REQUISITION
Test Schedule: Monday - Friday
0800-1600
Turnaround time from when specimen
is received in testing laboratory:
 
Routine
5 days
Stat
 
 
Reference Range: ADULT:

Osmolality (mOsm/kg)Copeptin Reference Interval (pmol/L)
270-280≤ 11.6
281-285≤ 13.7
286-2901.5-15.3
291-2952.3-24.5
296-3002.4-28.2


From Timper K et al., J Clin Endocrinol Metab 2015; 100(6):2268-2274:
a baseline copeptin ≥21.4 pmol/L identified nephrogenic diabetes insipidus with 100% sensitivity and specificity
following a combined water deprivation/hypertonic saline infusion test, a copeptin level ≥4.9 pmol/L identified primary polydipsia and a copeptin level <4.9 pmol/L identified complete or partial central diabetes insipidus, with 94-96% sensitivity and specificity

From Winzeler B et al., Lancet 2019; 394(10198):587-595:
at 60 min following an arginine stimulation test, a copeptin level ≥3.8 pmol/L identified primary polydipsia and a copeptin level <3.8 pmol/L identified complete or partial central diabetes insipidus, with 93% sensitivity and 92% specificity

PEDIATRIC:

Non-water-deprived pediatric subjects: copeptin reference interval <14.5 pmol/L

As suggested by a small study involving 15 children with polyuria and polydipsia from Tuli G et al., Clin Endocrinol (Oxf) 2018; 88(6):873-879:
following a water deprivation test:
 copeptin >20 pmol/L: nephrogenic diabetes insipidus
 copeptin 5-20 pmol/L: primary polydipsia
 copeptin 2.2-4.9 pmol/L: diagnosis depends on plasma and urine osmolality
 copeptin <2.2 pmol/L: complete central diabetes insipidus
Effective Date: 2019-03-04
Revised Date: 2019-11-01
Critical Value:  
Interpretive Comments:  
Special Processing:  
Comments:  
Method of Analysis: Thermo Fisher Fluorescent Immunoassay
Critical Information Required:  
Storage & Shipment: Store and ship plasma or serum frozen.
System Codes: 
Cerner
COPEP
 
Referred To:  

Questions? Comments? Contact Laura Gopaul