Laboratory Test Information Guide

Details for Cryoglobulin,Serum

Test Name: Cryoglobulin,Serum
Alternate Name(s):  
Laboratory: Clinical Immunology
Specimen Type: 2 x 6 mL Red (no gels or serum separator) top Vacutainer tubes
Collection Information: If possible, patient should be fasting.

Caution: Specimen is not acceptable when drawn on a patient receiving heparin or any other anti-coagulant. Serum only acceptable sample.

Heparin (Dalteparin) needs to be stopped 24 hours before sample can be collected. Lovenox needs to be stopped 35 hours before sample can be collected.

Immediately after the blood draw, label the tubes and place in a thermos with warm (not hot) water. Water should be 37C. Send to the laboratory specimen receiving area.

Do not leave the specimens at room temperature or refrigerate.
Transport the samples as soon as possible.
- Order CRYO
Test Schedule: Monday-Friday during regular work hours. No weekends or holidays.
Turnaround time from when specimen
is received in testing laboratory:
Final reports for Negatives: 7 days
Final reports for Positives: 10 days
Reference Range: Negative
Effective Date: 2010-01-11
Revised Date: 2018-08-21
Critical Value:  
Interpretive Comments: A preliminary report after 48 hours will be generated in Powerchart followed by a final report within 10 days.

The final report will include a calculated cryocrit and a characterization identifying the type of cryoglobulin present.

NOTE: The cryocrit will be used to monitor positive patients as the characterization will only be processed once.
Special Processing: The specimen tubes must remain at 37C until the serum has been separated.
Comments: If the cryo develops as a gel rather than flocculation, the crit may be technically impossible to perform.
Method of Analysis: Manual
Critical Information Required: Is the patient on heparin therapy?
Storage & Shipment: The specimen blood tubes must remain at 37C until the serum has been separated. After separation, the specimen can be stored or shipped at ambient temperature or refrigerated.
System Codes: 
Referred To:  

Questions? Comments? Contact Laura Gopaul