Laboratory Test Information Guide

Details for Free Light Chains, Serum/Plasma

Test Name: Free Light Chains, Serum/Plasma
Alternate Name(s): Free Kappa Light Chains
Free Lambda Light Chains
Serum Free Light Chains
Laboratory: Clinical Immunology
Specimen Type: Adult:
5 mL Gold top Vacutainer tube

Red, Light Green (Li-Heparin), or Lavender (EDTA) top tubes are also acceptable
Collection Information: Minimum volume of serum or plasma required is 750 ÁL.
Requisition: GENERAL LABORATORY REQUISITION
Test Schedule: Monday - Friday
0800-1600
Turnaround time from when specimen
is received in testing laboratory:
 
Routine
5 days
Stat
N/A
 
Reference Range: Free Kappa Chains: 3.3-19.4 mg/L
Free Lambda Chains: 5.7-26.3 mg/L
Kappa:Lambda ratio: 0.26-1.65
Adjusted Kappa:Lambda ratio for chronic kidney disease: 0.37-3.10
Effective Date: 2009-02-13
Revised Date: 2020-05-25
Critical Value:  
Interpretive Comments: A persistent and aberrant Kappa:Lambda ratio supports a diagnosis of monoclonal gammopathy.
Special Processing:  
Comments: Note: Serial free light chain analysis should only be performed for patients with AL amyloidosis, light chain myeloma, or non-secretory myeloma. If free light chain testing is ordered and it has been <20 days since the collection date of the last sample run, the test will be cancelled.
Method of Analysis: Immunoturbidimetry
Critical Information Required:  
Storage & Shipment: Store and ship serum or plasma refrigerated.
System Codes: 
Cerner
FLC
 
Referred To:  

Questions? Comments? Contact Laura Gopaul