Laboratory Test Information Guide

Details for Immune Complexes

Test Name: Immune Complexes
Alternate Name(s): Circulating immune complexes
IC
CIC
Laboratory: Clinical Immunology
Specimen Type: 5 mL Gold top Vacutainer tube or 6 mL Red top Vacutainer tube or EDTA plasma

Pediatric:
0-2 yrs: Red 1.0 pk.
2-10 yrs: 2 mL Red top
Collection Information: Minimum sample volume is 0.2 mL.

Fasting sample preferred. Sample should be separated within 60 minutes of phlebotomy collection
Requisition: GENERAL LABORATORY REQUISITION
Test Schedule: Batch Analysis – once/20 business days
Turnaround time from when specimen
is received in testing laboratory:
 
Routine
20 days
Stat
N/A
 
Reference Range: Negative: ≤19 RU/mL
Effective Date: 2010-01-11
Revised Date: 2018-07-13
Critical Value:  
Interpretive Comments: Results higher than top standard will be reported as >200 RU/mL.

CIC as measured by C1q binding are found sporadically in the normal population as a result of infection and can also be elevated after eating. Results from different technologies, methodologies and manufacturer’s kits may vary widely due to differences in standardization.

CIC testing is used to aid diagnosis only. CIC results are not diagnostic proof of the presence of absence of disease. Review the results in conjunction with history, and other diagnostic and serological tests.
Special Processing: Prepare two sample aliquots from the primary tube: store and ship frozen.

Repeated thawing and freezing should be avoided
Samples should NOT be heat inactivated, Heat inactivation results in false positive results.
Comments: This assay DOES NOT quantitate C1q protein.
Method of Analysis: Euroimmun Analyzer I-ELISA
Critical Information Required: Rheumatoid factor may interfere with analysis. Indicate if the patient is positive for rheumatoid factor.
Storage & Shipment: Store at -20oC or colder and ship on ice packs.
Avoid freeze/thaw cycles.
System Codes: 
Cerner
CIC
 
Referred To:  

Questions? Comments? Contact Laura Gopaul