Laboratory Test Information Guide

Details for Neuromyelitis Optica Spectrum Panel

Test Name: Neuromyelitis Optica Spectrum Panel
Alternate Name(s): Anti Myelin Oligodendrocyte Glycoprotein and Anti Aquaporin4, IgG
Anti AQP4 antibody
Anti NMO antibody
Anti MOG antibody
Laboratory: Clinical Immunology
Specimen Type: 5 mL Gold top or 6 mL Red top Vacutainer tube as well as EDTA, heparin or citrate plasma is acceptable

0-2 years: Red 0.5pk.
2-10 years: 2 mL Red top

CSF will also be accepted.
Note: CSF samples will also be accepted and only be processed if accompanied by a serum sample.
Collection Information: Minimum volume required for testing is 0.1 mL
Test Schedule: Batch analysis
Turnaround time from when specimen
is received in testing laboratory:
10 days
Reference Range: Negative
Effective Date: 2018-06-04
Revised Date: 2021-10-01
Critical Value:  
Interpretive Comments: This test can be used to help distinguish between Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorders (NMOSD).
Special Processing:  
Comments: This test is available to LHSC Neurologists only and accepted from referred in locations.
A single autoantibody test is not diagnostic and should not be used to determine course of treatment.
The test result must be evaluated with consideration of clinical presentation, patient history and other laboratory tests.
Method of Analysis: Recombinant Cell-based Immunofluorescence Assay (IFA)
Critical Information Required: Testing for AQP4 and MOG antibodies may be more sensitive in serum than in CSF. CSF testing should only be considered in patients receiving acute immunotherapy such as plasma exchange, and should be accompanied by a serum sample.
Storage & Shipment: The samples can be stored for up to 14 days at temperatures of 2-8oC. For longer storage, store at -20oC.
Avoid freeze/thaw cycles.
System Codes: 
Serum: NMOSD
Referred To:  

Questions? Comments? Contact Laura Gopaul