Laboratory Test Information Guide

Details for Porphyrin Screen and Quantitation, Random Urine

Test Name: Porphyrin Screen and Quantitation, Random Urine
Alternate Name(s): Uroporphyrin III
Heptacarboxylic acid
Hexacarboxylic acid
Pentacarboxylic acid
Coproporphyrin I
Coproporphyrin III
Laboratory: Core
Specimen Type: Random Urine
Collection Information: Collect urine in a sterile container with no preservative. Protect from light and send to the lab as soon as possible.

Minimum volume of urine required is 20 mL.

This collection is not suitable for ALA/PBG testing. See “Porphyrin Precursors” for ALA/PBG testing.
Test Schedule: Referred out Monday-Thursday
Turnaround time from when specimen
is received in testing laboratory:
10 days
Reference Range: Reference Range Screen: Normal

Creatinine (Cr): reference interval not available for random urine
Uroporphyrin III: ≤2.0 nmol/mmol Cr
Heptacarboxylic acid: ≤1.3 nmol/mmol Cr
Hexacarboxylic acid: ≤0.7 nmol/mmol Cr
Pentacarboxylic acid: ≤1.0 nmol/mmol Cr
Coproporphyrin I: 0.3-8.5 nmol/mmol Cr
Coproporphyrin III: 1.7-26.3 nmol/mmol Cr
Copro III/Copro I ratio: 2.6-5.3

Interpretation provided on report.

Reference intervals are for adults only and are not available for individuals 17 years of age or younger.
Effective Date: 2011-11-09
Revised Date: 2021-07-05
Critical Value:  
Interpretive Comments:  
Special Processing: pH should be adjusted to 8-10 with sodium carbonate immediately upon receipt in the lab. Keep specimen protected from light. Store and ship urine frozen.
Comments: Screen will be performed first. Quantitation will automatically be performed (and billed) if preliminary screen is positive.
Method of Analysis: Spectrophotometry and HPLC
Critical Information Required:  
Storage & Shipment: Store and ship urine frozen and protected from light.
System Codes: 
Referred To: In-Common Laboratories

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