Laboratory Test Information Guide

Details for Theophylline, Serum

Test Name: Theophylline, Serum
Alternate Name(s): Aminophylline
Theo-Dur
Somophyllin
Elixophyllin
Xanthine
Laboratory: Core
Specimen Type: Adult:
6 mL Red top Vacutainer tube

Pediatric:
0-2 years: 2 x 0.5 mL Red top Microtainers
2-10 years: 3 mL Red top Vacutainer tube
Collection Information: Minimum volume of serum required is 0.5 mL.
Avoid gel-separator tubes.
Draw specimens at trough concentration prior to next regular dose.
Peak concentration is obtained 2 hours post oral dose.
Steady state is achieved during continuous IV therapy.
In premature infants and some neonates, the active metabolite caffeine may require simultaneous monitoring.
Separate as soon as possible. Repeated freezing and thawing of samples should be avoided.
Grossly hemolyzed or icteric specimens will not be tested.
Requisition: GENERAL LABORATORY REQUISITION
Test Schedule: Referred out Monday – Thursday
Turnaround time from when specimen
is received in testing laboratory:
 
Routine
3 days
Stat
N/A
 
Reference Range: 55 - 110 µmol/L
Effective Date: 2010-08-31
Revised Date: 2019-06-04
Critical Value: Toxic: >110 µmol/L
Critical Value to be phoned to nurse or physician immediately
Interpretive Comments:  
Special Processing:  
Comments: Bronchodilator drug used in treatment of reversible bronchoconstriction.
Aminophylline is a salt of theophylline (80-85% by weight of this salt is theophylline).
Method of Analysis: KIMS (Immunoassay)
Critical Information Required:  
Storage & Shipment: Store and ship serum frozen.

Specimen Stability:
Ambient: 8 hours
Refrigerated: 7 days
Frozen: 2 months
System Codes: 
Cerner
THEO
 
Referred To: In-Common Laboratories

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