Laboratory Test Information Guide

Details for Vanillylmandelic Acid, Urine

Test Name: Vanillylmandelic Acid, Urine
Alternate Name(s): VMA
Laboratory: Toxicology/Special Chemistry
Specimen Type: 24-hour urine or random urine. Random urine testing available for pediatric patients only.
Collection Information: 24-Hour Urine Diet and Medication Restrictions: 5-HIAA, Catecholamines, Metanephrines, VMA/HVA, Serotonin

Collection of a 24-Hour Urine Sample

For 24-hour urine:
Collect urine over a 24-hour period in a container with 30 mL of 6 N HCl for adult samples or 15 mL of 6 N HCl for pediatric samples.

For random urine:
Obtain a container with 0.5 mL of 6 N HCl from the core laboratory prior to urine collection. Minimum volume of urine required is 1 mL.
Test Schedule: Monday – Friday
Turnaround time from when specimen
is received in testing laboratory:
5 days
2 days
Reference Range: Random Urine (VMA in µmol/mmol creatinine):
0 - 2 years: ≤ 10.7
2 - 4 years: ≤ 6.3
5 - 9 years: ≤ 4.7
10 - 19 years: ≤ 5.0
> 19 years: ≤ 3.5

24-Hour Urine (VMA in µmol/day):
0 - 2 years: ≤ 12.0
2 - 4 years: ≤ 15.0
5 - 9 years: ≤ 18.0
10 - 19 years: ≤ 30.0
> 19 years: ≤ 34.0
Effective Date: 2017-07-04
Revised Date: 2021-10-22
Critical Value:  
Interpretive Comments:  
Special Processing: For 24-hour urine collections, transfer an aliquot of the measured urine to a 5-mL Greiner tube.
Comments: VHHU24 (for 24-hour urine; includes VMA and HVA) or VMAR (for random urine; includes VMA and HVA)

Orders for VMA and HVA are coupled so that the levels of both analytes are measured and reported for each sample.

For STAT requests, please call the toxicology lab at ext. 64664 to make arrangements.
Method of Analysis: LC-MS/MS
Critical Information Required:  
Storage & Shipment: Store and ship urine aliquot refrigerated.
System Codes: 
See Comments
Referred To:  

Questions? Comments? Contact Laura Gopaul